Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting.
Elizabeth A BemisM Kristen DemoruelleJennifer A SeifertKristen J PolinskiMichael H WeismanJane H BucknerPeter K GregersenTed R MikulsJames R ODellRichard M KeatingKevin D DeaneV Michael HolersJill M NorrisPublished in: Annals of the rheumatic diseases (2020)
These findings support that aAb screening in a non-clinical setting can identify RA-related aAb+ individuals, as well as levels and combinations of aAbs that are associated with higher risk for future IA. Monitoring for the development of IA in aAb+ individuals and similar aAb testing approaches in at-risk populations may identify candidates for prevention studies in RA.