Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers.
Nickolas J NahmW G Stuart MackenzieWilliam G MackenzieEthan GoughSyed Shahrukh HashmiJacqueline T HechtJanet M LegareMary Ellen LittlePeggy ModaffRichard M PauliDavid F Rodriguez-BuriticaMaria Elena SernaCory J SmidJulie Elizabeth Hoover-FongMichael B BoberPublished in: Orphanet journal of rare diseases (2023)
Orthopedic surgery was a common occurrence in achondroplasia with 29.7% of patients undergoing at least one orthopedic procedure. Spine surgery (12.7%) was less common and occurred at a later age than lower extremity surgery (21.2%). Cervicomedullary decompression and hydrocephalus with shunt placement were associated with an increased risk for spine surgery. The results from CLARITY, the largest natural history study of achondroplasia, should aid clinicians in counseling patients and families about orthopedic surgery.
Keyphrases
- minimally invasive
- coronary artery bypass
- patients undergoing
- surgical site infection
- ejection fraction
- newly diagnosed
- percutaneous coronary intervention
- palliative care
- brain injury
- subarachnoid hemorrhage
- prognostic factors
- smoking cessation
- patient reported
- pulmonary hypertension
- pulmonary artery
- pulmonary arterial hypertension
- antiretroviral therapy