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Intrinsic Strain-Mediated Ultrathin Ceria Nanoantioxidant.

Cong LiuLin GuiJia-Jia ZhengYong-Qiang XuBenli SongLi YiYijiang JiaAyijiang TaledaohanYuji WangXuejiao J GaoZeng-Ying QiaoHao WangZhiyong Tang
Published in: Journal of the American Chemical Society (2023)
Metal oxide nanozymes have emerged as the most efficient and promising candidates to mimic antioxidant enzymes for treatment of oxidative stress-mediated pathophysiological disorders, but the current effectiveness is unsatisfactory due to insufficient catalytic performance. Here, we report for the first time an intrinsic strain-mediated ultrathin ceria nanoantioxidant. Surface strain in ceria with variable thicknesses and coordinatively unsaturated Ce sites was investigated by theoretical calculation analysis and then was validated by preparing ∼1.2 nm ultrathin nanoplates with ∼3.0% tensile strain in plane/∼10.0% tensile strain out of plane. Compared with nanocubes, surface strain in ultrathin nanoplates could enhance the covalency of the Ce-O bond, leading to increasing superoxide dismutase (SOD)-mimetic activity by ∼2.6-fold (1533 U/mg, in close proximity to that of natural SOD) and total antioxidant activity by ∼2.5-fold. As a proof of concept, intrinsic strain-mediated ultrathin ceria nanoplates could boost antioxidation for improved ischemic stroke treatment in vivo , significantly better than edaravone, a commonly used clinical drug.
Keyphrases
  • oxidative stress
  • systematic review
  • high efficiency
  • emergency department
  • metal organic framework
  • atrial fibrillation
  • combination therapy
  • quantum dots
  • heat shock
  • induced apoptosis
  • single molecule
  • energy transfer