Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors.
Ole Marius OtterleiDaniel J IndelicatoLaura ToussaintKristian S Ytre-HaugeSara PilskogLars Fredrik FjaeraEivind RørvikHelge Egil Seime PettersenLudvig P MurenYasmin Lassen-RamshadMarcos Di PintoCamilla Hanqvuist StokkevågPublished in: Acta oncologica (Stockholm, Sweden) (2020)
For all BSCs, there was a systematic model-dependent variation in RBEd, mirroring the uncertainty in biological effects of protons. According to a refined selection of in vitro models, the RBE variation across BSCs was in effect underestimated when using a fixed RBE of 1.1.