Cytotoxicity of 3D-printed, milled, and conventional oral splint resins to L929 cells and human gingival fibroblasts.

Ralf BürgersAndrea SchubertJonas MüllerSebastian KrohnMatthias RödigerAndreas LehaTorsten Wassmann

Published in: Clinical and experimental dental research (2022)

The cytotoxic effects of 3D-printed, milled, and conventional oral splint resins were similar, indicating minor influence of the manufacturing method on biocompatibility. Cytotoxicity of the resins was below a critical threshold in GF1 cells. The chemical composition might be more crucial than the manufacturing method for the biocompatibility of splint resins.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
cell death
oxidative stress
extracellular matrix
anti inflammatory