Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.
Eva Tonsing-CarterKyle M HernandezCaroline R KimRyan V HarklessAlyce OhKathleen R BowieDiana C West-SzymanskiMayra A Betancourt-PonceBradley D GreenRicardo R LastraGini F FlemingSarat ChandarlapatySuzanne D ConzenPublished in: Breast cancer research : BCR (2019)
These studies demonstrate that liganded GR can suppress ER chromatin occupancy at shared ER-regulated enhancers, including CCND1 (Cyclin D1), regardless of whether the ligand is a classic GR agonist or antagonist. Resulting GR-mediated suppression of ER+ BC proliferative gene expression and cell division suggests that SGRMs could decrease ER-driven gene expression.