Effect of diuretics on plasma renin activity in primary hypertension: A systematic review and meta-analysis.
Ryan John McnallyLuca FacontiMarina CeceljaBushra FarukhChristopher Nicholas FloydPhilip J ChowienczykPublished in: British journal of clinical pharmacology (2021)
In antihypertensive drug trials, diuretics lead to a sustained increase in average PRA, which is similar across different classes of diuretic and unrelated to the average reduction in blood pressure.