A macrocycle directed total synthesis of di-O-methylendiandrin A.
Timothy H BarnesKara F JohnsonJohn D GordenBradley L MernerPublished in: Chemical communications (Cambridge, England) (2020)
The total synthesis of the lignan-based cyclobutane di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone as key transformations for establishing relative stereochemistry and furnishing the strained 4-membered ring of the natural product.