CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension.
Jonathan H WardmanSøren Norge AndreassenTrine L Toft-BertelsenMette Nyholm JensenJens E WilhjelmBjarne StyrishaveSteffen HamannSteffen HeegaardAlexandra J SinclairNanna MacAulayPublished in: Fluids and barriers of the CNS (2024)
Obesity in itself therefore does not suffice to recapitulate the IIH symptoms in rats, but modulation of CSF dynamics appears with adjuvant testosterone treatment, which mimics the androgen excess observed in female IIH patients. Obesity-induced androgen dysregulation may thus contribute to the disease mechanism of IIH and could potentially serve as a future therapeutic target.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- end stage renal disease
- weight gain
- ejection fraction
- blood pressure
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- adipose tissue
- prognostic factors
- high glucose
- cerebrospinal fluid
- skeletal muscle
- diabetic rats
- patient reported outcomes
- sleep quality
- depressive symptoms
- combination therapy
- drug induced
- physical activity