USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.

Yang SuChenming WuYiming ChangLei LiYuping ChenXuebing JiaXinshu WangYing LvBentong YuJian Yuan

Published in: Breast cancer research and treatment (2022)

Our results highlighted that USP17L2 regulates the chemoresistance of breast cancer cells in a SIRT7-dependent manner. Moreover, the role of USP17L2 as a potential therapeutic target in breast cancer and a prognostic factor for patients was elucidated.

Keyphrases

prognostic factors
breast cancer cells
dna damage
oxidative stress
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
ischemia reperfusion injury
dna repair
climate change
risk assessment
cancer stem cells
patient reported