Chronic hypoxia promoted pulmonary arterial smooth muscle cells proliferation through upregulated calcium-sensing receptorcanonical transient receptor potential 1/6 pathway.
Juan XuXing WenZhenli FuYongliang JiangWei HongRongmin LiuShaoxing LiWeitao CaoJinding PuLingmei HuangBing LiPixin RanGongyong PengPublished in: Microcirculation (New York, N.Y. : 1994) (2021)
These results demonstrate that upregulated CaSR-TRPC1/6 pathway mediating PASMCs proliferation is an important pathogenic mechanism under hypoxic conditions.