A physiologically based pharmacokinetic modelling approach to predict buprenorphine pharmacokinetics following intravenous and sublingual administration.

Hari Varun KalluriHongfei ZhangSteve N CaritisRaman Venkataramanan

Published in: British journal of clinical pharmacology (2017)

The validated PBPK models will be used in future studies to predict BUP plasma and brain concentrations based on the varying demographic, physiological and pathological characteristics of patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
high dose
low dose
current status
multiple sclerosis
blood brain barrier
subarachnoid hemorrhage
cerebral ischemia
case control
functional connectivity