Management of isocitrate dehydrogenase 1/2 mutated acute myeloid leukemia.
Harry FruchtmanZachary M AviganJulian A WaksalNicole BrennanJohn O MascarenhasPublished in: Leukemia (2024)
The emergence of next generation sequencing and widespread use of mutational profiling in acute myeloid leukemia (AML) has broadened our understanding of the heterogeneous molecular basis of the disease. Since genetic sequencing has become a standard practice, several driver mutations have been identified. Accordingly, novel targeted therapeutic agents have been developed and are now approved for the treatment of subsets of patients that carry mutations in FLT3, IDH1, and IDH2 [1, 2]. The emergence of these novel agents in AML offers patients a new modality of therapy, and shifts treatment paradigms toward individualized medicine. In this review, we outline the role of IDH mutations in malignant transformation, focus in on a novel group of targeted therapeutic agents directed toward IDH1- and IDH2-mutant AML, and explore their impact on prognosis in patients with AML.
Keyphrases
- acute myeloid leukemia
- wild type
- end stage renal disease
- low grade
- newly diagnosed
- ejection fraction
- allogeneic hematopoietic stem cell transplantation
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- healthcare
- single cell
- primary care
- cancer therapy
- copy number
- gene expression
- peripheral blood
- quality improvement
- high grade
- mesenchymal stem cells
- cell therapy
- combination therapy