Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling.
Udayakumar KarunakaranEun Yeong HaSuma ElumalaiKyu Chang WonJun Sung MoonPublished in: Journal of diabetes investigation (2024)
Mitochondrial ALDH2 activation could inhibit the progression of doxorubicin induced pancreatic β-cell dysfunction by inhibiting the acid sphingomyelinase induction of ceramide, by regulating the activation of CK2 signaling. Our research lays the foundation of ALDH2 activation as a therapeutic target for the precise treatment of chemotherapy drug induced β-cell dysfunction.
Keyphrases
- drug induced
- oxidative stress
- induced apoptosis
- liver injury
- diabetic rats
- signaling pathway
- single cell
- endoplasmic reticulum stress
- cell therapy
- drug delivery
- cancer therapy
- protein kinase
- stem cells
- high glucose
- squamous cell carcinoma
- locally advanced
- mesenchymal stem cells
- electronic health record
- rectal cancer
- replacement therapy