Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion-compression model.

Hao ZhangAlexander YounsiGuoli ZhengMohamed TailAnna-Kathrin HarmsJudith RothMaryam HatamiThomas SkutellaAndreas UnterbergKlaus Zweckberger

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2021)

Intrathecal Shh-administration showed neuroprotective effects with attenuated neuroinflammation, reduced astrogliosis and improved functional recovery six weeks after severe contusion/compression SCI.

Keyphrases

spinal cord
inflammatory response
spinal cord injury
lipopolysaccharide induced
lps induced
traumatic brain injury
toll like receptor
early onset
cognitive impairment
gestational age
cerebral ischemia
drug induced
subarachnoid hemorrhage
brain injury
preterm birth