Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease.
Davina BielYing LuanMatthias BrendelPaul HagerAnna DewenterAlexis MoscosoDiana Otero SvaldiIxavier A HigginsMichael PontecorvoSebastian RömerAnna StewardAnna RubinskiLukai ZhengMichael SchöllSergey ShcherbininMichael EwersNicolai Franzmeiernull nullPublished in: Alzheimer's research & therapy (2022)
Combining tau-PET with task-fMRI-derived maps of major cognitive domains facilitates the prediction of domain-specific cognitive decline. This approach may help to increase the sensitivity to detect Alzheimer's disease-related cognitive decline and to determine personalized cognitive endpoints in clinical trials.