Glycine increases glyoxalase-1 function by promoting nuclear factor erythroid 2-related factor 2 translocation into the nucleus of kidney cells of streptozotocin-induced diabetic rats.
Ziwei WangDan ZhaoLei ChenJingjing LiGeheng YuanGuosheng YangHong ZhangXiaohui GuoJunqing ZhangPublished in: Journal of diabetes investigation (2019)
The present study shows that glycine might enhance the function of Glo1 and restore anti-oxidant defense by promoting the nuclear translocation of Nrf2, thus inhibiting advanced glycation end-products formation and protecting against renal oxidative stress.