Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study.

Jingran JiCan-Lan SunHarvey J CohenTimothy SynoldHyman B Muss Mina S Sedrak

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

In this cohort of older women with early breast cancer who were clinically fit before chemotherapy initiation, high IL-6 and CRP prechemotherapy were associated with chemotherapy-induced decline in frailty status independent of sociodemographic and clinical risk factors. Further research is needed to examine whether inflammatory markers can inform more personalized approaches to treating older breast cancer survivors.

Keyphrases

chemotherapy induced
risk factors
community dwelling
physical activity
early breast cancer
middle aged
squamous cell carcinoma
radiation therapy
rectal cancer