SARS-CoV-2, COVID-19 and Parkinson's Disease-Many Issues Need to Be Clarified-A Critical Review.
Tsepo GoerttlerEun-Hae KwonMichael FleischerMark StettnerLars TöngesStephan KlebePublished in: Brain sciences (2022)
Neurological manifestations during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are of interest, regarding acute treatment and the so-called post-COVID-19 syndrome. Parkinson's disease (PD) is one of the most common neurodegenerative movement disorders worldwide. Hence, the influence of SARS-CoV-2 and the COVID-19 syndrome on PD patients has raised many questions and produced various publications with conflicting results. We reviewed the literature, with respect to symptoms, treatment, and whether the virus itself might cause PD during the SARS-CoV-2 pandemic in SARS-CoV-2-affected symptomatic PD patients (COVID-19 syndrome). In addition, we comment on the consequences in non-symptomatic and non-affected PD patients, as well as post-COVID syndrome and its potential linkage to PD, presenting our own data from our out-patient clinic.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- newly diagnosed
- ejection fraction
- case report
- prognostic factors
- systematic review
- gene expression
- primary care
- genome wide
- patient reported outcomes
- brain injury
- hiv infected
- electronic health record
- combination therapy
- deep learning
- acute respiratory distress syndrome
- men who have sex with men
- mechanical ventilation