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Direct interhemispheric cortical communication via thalamic commissures: a new white-matter pathway in the primate brain.

Diego SzczupakDavid J SchaefferXiaoguang TianSang-Ho Choinull Fang-ChengPamela Meneses IackVinicius P CamposJ Patrick MayoJanina PatschChristian MitterAmit HabooshehMarcelo A C VieiraGregor J KasprianFernanda Tovar-MollRoberto LentAfonso C Silva
Published in: bioRxiv : the preprint server for biology (2023)
Brain connectivity is a central topic in neuroscience. Understanding how brain areas can communicate allows for the comprehension of brain structure and function. We have described in rodents a new commissure pathway that connects the cortex to the contralateral thalamus. Here, we investigate whether this pathway exists in non-human primates and humans. The presence of these commissures poses the TCs as an important fiber pathway in the primate brain, allowing for more robust interhemispheric connectivity and synchrony and serving as an alternative commissural route in developmental brain malformations.
Keyphrases
  • white matter
  • resting state
  • functional connectivity
  • multiple sclerosis
  • cerebral ischemia
  • endothelial cells