Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report.

Lindsay WilsonJu-Wei ChangStuart MeierTariq GaniefNaadir GaniefSuzette OelofseVicky BaillieMarta C NunesShabir A MadhiJonathan BlackburnKeertan Dheda

Published in: Open forum infectious diseases (2023)

The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus

machine learning
respiratory failure
community acquired pneumonia

single cell
intensive care unit
deep learning

binding protein
amino acid