A multi-breed reference panel and additional rare variants maximize imputation accuracy in cattle.

Troy N Rowan Jesse L Hoff Tamar E Crum Jeremy F Taylor Robert D Schnabel Jared E Decker

Published in: Genetics, selection, evolution : GSE (2019)

Using high-density genotypes on all available individuals in a multi-breed reference panel maximized imputation accuracy for tested cattle populations. Admixed animals or those from breeds with a limited representation in the composite reference panel were still imputed at high accuracy, which is expected to further increase as the reference panel expands. We anticipate that the addition of rare variants from the GGP-F250 assay will increase the accuracy of imputation to sequence level.

Keyphrases

high density
copy number
high throughput
gene expression
genome wide
amino acid
neural network