Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation.

Emilia SolomonKatie Davis-AndersonBlake HovdeSofiya N Micheva-VitevaJennifer Foster HarrisScott TwaryRashi Iyer

Published in: BMC molecular and cell biology (2021)

Detailed transcriptome profile of each developmental step from iPSC to motor neuron driven by chemical induction provides the guidelines to novel therapeutic approaches in the re-construction efforts of muscle innervation.

Keyphrases

rna seq
single cell
genome wide
gene expression
induced pluripotent stem cells
skeletal muscle
clinical practice
quality improvement
dna methylation