Therapeutic effect and mechanism of Daikenchuto in a model of methotrexate-induced acute small intestinal mucositis.

Peilin LiYusuke InoueDaisuke MiyamotoToshiyuki AdachiSatomi OkadaTomohiko AdachiAkihiko SoyamaMasaaki HidakaKengo KanetakaShinichiro ItoDaichi SadatomiSachiko MogamiNaoki FujitsukaWeili GuSusumu Eguchi

Published in: PloS one (2023)

DKT protected against MTX-induced CIM in a rat model by reducing inflammation, stimulating cell proliferation, and stabilizing the mucosal barrier.

Keyphrases

cell proliferation
oxidative stress
diabetic rats
high glucose
high dose
radiation induced
drug induced
signaling pathway
radiation therapy