In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus.

Bettina Schulthess Fatma Nur Akdoğan KittanaRico HömkePeter Sander

Published in: Antimicrobial agents and chemotherapy (2022)

Bedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus. We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for in vitro susceptibility testing for bedaquiline and clofazimine in M. abscessus.

Keyphrases

drug resistant
multidrug resistant
mycobacterium tuberculosis
big data
machine learning
artificial intelligence