The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity.
Sara A ThannickalLeandro BattiniSophie N SpectorMaria G NovalDiego E ÁlvarezKenneth A StaplefordPublished in: bioRxiv : the preprint server for biology (2023)
. Here, we show that changes in the CHIKV E1 fusion loop and hinge contribute to host-specific entry and E1-E2 dynamics, furthering our knowledge of how alphaviruses infect mammals and insects.