Protective Mechanism of MIF Inhibitor ISO-1 on Intrahepatic Bile Duct Cells in Rats with Severe Acute Pancreatitis.

Bin WangKailiang ZhaoWenjuan HuYouming DingWeixing Wang

Published in: Digestive diseases and sciences (2020)

ISO-1 may protect the IBD cells, reduce pathological injuries, and reduce the inflammatory response in SAP rats. Its mechanisms may be via inhibiting the expression of MIF and then blocking the activation of p38-MAPK and NF-κB signaling pathway.

Keyphrases

signaling pathway
induced apoptosis
cell cycle arrest
inflammatory response
pi k akt
oxidative stress
endoplasmic reticulum stress
epithelial mesenchymal transition
early onset
long non coding rna