Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Li ChenJun DongSiyang LiaoSiyou WangZhida WuMeiling ZuoBing LiuChaojun YanYong ChenHe HeQingtao MengZhiyin SongPublished in: Hepatology (Baltimore, Md.) (2022)
Our findings uncover the critical role of Sam50 in maintaining mitochondrial membrane integrity and mtDNA stability in hepatocytes and reveal that Sam50 depletion-induced cardiolipin externalization is a signal of mtDNA release and controls mtDNA-dependent innate immunity.