The Lrat-/- Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa.

Céline KosterKoen T van den HurkColby F LewallenMays TalibJacoline B Ten BrinkCamiel J F BoonArthur A Bergen

Published in: International journal of molecular sciences (2021)

Our Lrat-/- rat is a new animal model for retinal dystrophy, especially for the LRAT-subtype of early-onset retinal dystrophies. This model has advantages over the existing mouse models and the RCS rat strain and can be used for translational studies of retinal dystrophies.

Keyphrases

early onset
optical coherence tomography
diabetic retinopathy
crispr cas
late onset
oxidative stress
optic nerve
mouse model
high throughput
case control