From science to business: translating live biotherapeutic products to the clinic.

Published in: Nature reviews bioengineering (2023)

At Pulmobiotics, we engineer bacteria for the treatment of respiratory diseases. Here, we outline how we designed MycoChassis - an attenuated bacterium strain obtained by genome engineering of Mycoplasma pneumoniae (a human lung pathogen) - and discuss the challenges on the road to its clinical translation.

Keyphrases

respiratory tract
public health
primary care
candida albicans
genome wide
gene expression
smoking cessation