A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus.
Mehdi Fazel-NajafabadiLoren L LoogerHarikrishna Reddy RallabandiSwapan K NathPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
We demonstrate and validate post-GWAS strategies for using multidimensional data to prioritize likely causal variants with cognate gene targets underlying SLE pathogenesis. Our results provide a catalog of significantly SLE-associated SNPs and loci, target genes, and likely biochemical mechanisms to guide experimental characterization.
Keyphrases
- systemic lupus erythematosus
- genome wide
- genome wide association study
- copy number
- disease activity
- dna methylation
- genome wide identification
- genome wide analysis
- bioinformatics analysis
- electronic health record
- transcription factor
- big data
- rheumatoid arthritis
- heat shock
- machine learning
- artificial intelligence
- gene expression
- oxidative stress
- psychometric properties
- genome wide association
- data analysis
- heat stress