Pharmacological characterization of the cardiovascular effect of Nibethione: ex vivo, in vivo and in silico studies.

Amanda Sánchez-Recillas Gabriel Navarrete-Vazquez Sergio Hidalgo-Figueroa Marcos Bonilla-Hernández Rolffy Ortiz Andrade Maximiliano Ibarra-Barajas Víctor Yáñez-Pérez Juan Carlos Sánchez-Salgado

Published in: The Journal of pharmacy and pharmacology (2020)

Nibethione showed in vivo antihypertensive and ex vivo vasorelaxant effects with implication of voltage-dependent L-type Ca2+ channel blocking, and this may contribute to the research of novel antihypertensive drugs.

Keyphrases

blood pressure
hypertensive patients
molecular docking
case control
protein kinase
drug induced