Maternal Antibody Response and Transplacental Transfer Following SARS-CoV-2 Infection or Vaccination in Pregnancy.

Sebastian OteroEmily S MillerAshwin SunderrajElisheva D ShanesAllie SakowiczJeffery A GoldsteinLeena B Mithal

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

COVID-19 vaccination in pregnancy leads to higher and longer lasting maternal IgG levels, higher cord blood IgG, and higher transfer ratio after 90 days compared to SARS-CoV-2 infection. Greater infection severity leads to higher maternal and cord blood antibodies. Maternal IgG decreases over time following both vaccination and infection, reinforcing the importance of vaccination, even after infection, and vaccine boosters for pregnant patients.

Keyphrases

cord blood
pregnancy outcomes
birth weight
pregnant women
end stage renal disease
ejection fraction
coronavirus disease
newly diagnosed
preterm birth
peritoneal dialysis
chronic kidney disease
prognostic factors
weight loss
patient reported