Intracranial Granular Cell Tumours in Three Dogs: Atypical Magnetic Resonance Imaging Features and Immunohistochemical Study.
Clàudia MayorJudit VerdésJaume AlomarRosa NovellasMarti PumarolaSònia AñorPublished in: Veterinary sciences (2023)
Intracranial granular cell tumours (GCT) are uncommon neoplasms of uncertain cellular origin that are rarely reported in dogs. This case series describes three aged dogs that presented with neurological signs in which magnetic resonance (MR) imaging revealed plaquelike extra-axial lesions that were hypointense on T2-weighted (T2w) images. The surgical biopsy of the lesions and necropsies were followed by histochemical characterisation with periodic acid-Schiff (PAS) staining and immunohistochemistry with ubiquitin, S-100, and SOX-10 to elucidate the cellular origin. The immunohistochemical study indicated that these intracranial GCTs were not of Schwann cell origin. In conclusion, GCTs should be considered a differential diagnosis of intracranial, extra-axial hypointense brain lesions on T2w MR images.
Keyphrases
- magnetic resonance
- single cell
- contrast enhanced
- magnetic resonance imaging
- cell therapy
- deep learning
- optic nerve
- stem cells
- convolutional neural network
- optical coherence tomography
- transcription factor
- machine learning
- resting state
- multiple sclerosis
- white matter
- blood brain barrier
- functional connectivity
- brain injury