IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
Chao LiShiqian LiGuangyu ZhangQinfeng LiWeidan SongXiaoding WangJane A CookMiesje M van der StoelBradley W WrightFrancisco AltamiranoErica L NiewoldJungsoo HanGarrett KimblePengfei ZhangXiang LuoHery UrraHerman I MayAnwarul FerdousXue-Nan SunYingfeng DengElina IkonenClaudio HetzAlexandre Rosa CamposKezhong ZhangThomas G GilletteJan-Bernd FunckeJoseph A HillJin ChenZhao V WangPublished in: Circulation (2024)
These studies suggest a noncanonical, essential role of IRE1α in orchestrating protein synthesis, which may have important implications in cardiac hypertrophy in response to pressure overload and general cell growth under other physiological and pathological conditions.