Synthesis and Preclinical Evaluation of the Fibrin-Binding Cyclic Peptide 18F-iCREKA: Comparison with Its Contrasted Linear Peptide.

Yin Zhang Lijuan Wang Sirui Yu Kongzhen Hu Shun Huang Youcai Li Hubing Wu Hongsheng Li Quan-Shi Wang

Published in: Contrast media & molecular imaging (2019)

The novel CREKA-based probe 18F-NOTA-iCREKA could get a high uptake in U87MG cells and high T/M ratio in U87MG mice. It was more stable and specific than the 18F-NOTA-LP.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
cell therapy
quantum dots
signaling pathway
high fat diet induced
cell death
metabolic syndrome
adipose tissue
endoplasmic reticulum stress
binding protein
dna binding
transcription factor
wild type