Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.

Lin ChengShichao ZhouShaoqing ZhouKaixuan ShiYan ChengMei-Chun CaiKaiyan YeLifeng LinZhenfeng ZhangChenqiang JiaHuaijiang XiangJingyu ZangMeiying ZhangXia YinYing LiWen DiGuanglei ZhuangLi Tan

Published in: Cancer research (2022)

This study dissects the specific roles of CDK12 and CDK13 in ovarian cancer and develops a CDK12/CDK13 inhibitor that impairs both tumor and immune cells, which could guide future CDK12 inhibitor development.

Keyphrases

cell cycle
cell proliferation