Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models.
Aart van der MeijdenVincent Aranzana-ClimentHeleen van der SpekBrenda C M de WinterWilliam CouetJoseph MeletiadisAnouk E MullerSanne van den BergPublished in: The Journal of antimicrobial chemotherapy (2023)
This study confirms that fAUC/MIC can describe the exposure-response relationship for polymyxin B. The 1 log kill effect was achieved in the minority of the isolates whereas polymyxin B PK/PD targets cannot be attained for the majority of clinical isolates with the standard dosing regimen, indicating that polymyxin B may be not effective against serious infections as monotherapy.