THE ROLE OF THE NEUROENDOCRINE SYSTEM IN THE PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE.
L S SelivanovaA S TertychnyyPublished in: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (2018)
Ulcerative colitis and Crohn's disease are both characterized by chronic, relapsing intestinal inflammation. The aetiology of both forms of inflammatory bowel disease (IBD) is still unknown. A potentially interesting area is the immunoregulatory role of enteric neuroendocrine system and neuroendocrine cells. Neuropeprides, like substance F', somatostatin, vasoactive intestinal peptide and calcitonin gene related peptide, are the molecular mediators of neuroregulation of the intestinal immune system, providing for interactions between nervous system and imniunocytes. In this review the role of neuroendocrine system and its neuroimmune modulators in IBD will be highlighted, together with their possible future use in the treatment of IBD.
Keyphrases
- ulcerative colitis
- multiple sclerosis
- induced apoptosis
- oxidative stress
- small molecule
- genome wide
- cell cycle arrest
- gene expression
- dna methylation
- copy number
- systemic lupus erythematosus
- rheumatoid arthritis
- cell death
- transcription factor
- signaling pathway
- cell proliferation
- disease activity
- replacement therapy
- genome wide identification
- smoking cessation