The Activity and Polymorphism of the PON1 in Patients with Chronic Liver Disease: a Systematic Review and Meta-analysis.

The results of this study demonstrate that the polynomorphism of the PON1 is associated with an increased risk of liver disease, with lower levels of PON1 activity in people with liver disease than in healthy patients and this decrease was more in patients with liver cirrhosis than in other liver diseases. Given the importance of this gene's activity, studies such as this could provide a promising path for better drug design and treatment in future.