Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling.

Gantumur DolgormaaNorifumi HarimotoNorihiro IshiiTakahiro YamanakaKei HagiwaraMariko TsukagoshiTakamichi IgarashiAkira WatanabeNorio KuboKenichiro ArakiTadashi HandaTakehiko YokoboriTetsunari OyamaHiroyuki KuwanoKen Shirabe

Published in: British journal of cancer (2020)

M2BPGi is produced in stromal cells of the cirrhotic liver. Furthermore, M2BPGi enhances the progression of HCC through the galectin-3/mTOR pathway.

Keyphrases

binding protein
cell proliferation
signaling pathway