Inter- and intra-individual concentrations of direct oral anticoagulants: The KIDOAC study.
Myrthe M A TooropNienke van ReinMelchior C NiermanHelga W VermaasMenno V HuismanFelix J M van der MeerSuzanne C CannegieterWillem M LijferingPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Inter-individual variability of DOAC concentrations was higher than intra-individual variability. Lower previous VKA dosage and creatinine clearance were associated with higher DOAC trough concentrations. These findings support further study into an optimal target range, in which the risks of both bleeding and thrombosis are minimal.