Oral administration of Bifidobacterium longum ES1 reduces endometrial inflammation in women with recurrent pregnancy loss.

Chiara TersigniGreta BarbaroRoberta CastellaniMarianna OnoriChiara GranieriGiovanni ScambiaNicoletta Di Simone

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)

RPL women positive for HLA-DQ2/DQ8 haplotype show increased circulating and endometrial levels of LPS and endometrial inflammasome NALP-3 over-activation. Oral administration of GliadinES® can reduce gut permeability, decrease serum levels of LPS and, contextually, improve endometrial inflammation in this specific subset of RPL women.

Keyphrases

endometrial cancer
pregnancy outcomes
oxidative stress
polycystic ovary syndrome
inflammatory response
pregnant women
preterm birth
adipose tissue
breast cancer risk