Intravitreal Methotrexate.
Fatemeh AbdiS Saeed MohammadiKhalil Ghasemi FalavarjaniPublished in: Journal of ophthalmic & vision research (2021)
Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative vitreoretinopathy, diabetic retinopathy, age-related macular degeneration, and uveitis were reviewed and the adverse effects of intravitreal injection of MTX were discussed. The most common indications are intraocular lymphoma and uveitis. Other applications remain challenging and more studies are needed to establish the role of intravitreal MTX in the management of ocular diseases.
Keyphrases
- age related macular degeneration
- diabetic retinopathy
- vascular endothelial growth factor
- optical coherence tomography
- high dose
- juvenile idiopathic arthritis
- emergency department
- low dose
- endothelial cells
- cataract surgery
- systemic lupus erythematosus
- smoking cessation
- combination therapy
- replacement therapy
- adverse drug