The Medical versus Zoological Concept of Outflow Tract Valves of the Vertebrate Heart.
Valentín Sans-ComaBárbara Pozo-VilumbralesMaría Carmen FernándezMiguel A López-UnzuMaría Teresa Soto-NavarreteAna Carmen DuránJosep M ArquéBorja FernándezPublished in: Journal of cardiovascular development and disease (2022)
The anatomical elements that in humans prevent blood backflow from the aorta and pulmonary artery to the left and right ventriclesare the aortic and pulmonary valves, respectively. Each valve regularly consists of three leaflets (cusps), each supported by its valvular sinus. From the medical viewpoint, each set of three leaflets and sinuses is regarded as a morpho-functional unit. This notion also applies to birds and non-human mammals. However, the structures that prevent the return of blood to the heart in other vertebrates are notably different. This has led to discrepancies between physicians and zoologists in defining what a cardiac outflow tract valve is. The aim here is to compare the gross anatomy of the outflow tract valvular system among several groups of vertebrates in order to understand the conceptual and nomenclature controversies in the field.
Keyphrases
- aortic valve
- pulmonary artery
- pulmonary hypertension
- transcatheter aortic valve replacement
- aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- coronary artery
- pulmonary arterial hypertension
- healthcare
- atrial fibrillation
- heart failure
- endothelial cells
- primary care
- high resolution
- induced pluripotent stem cells
- mitral valve
- coronary artery disease
- mass spectrometry
- ejection fraction