RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells.

Luz P Blanco Xinghao Wang Philip M CarlucciJose Jiram Torres-RuizJorge Romo-TenaHong-Wei SunMarkus HafnerMariana J Kaplan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

These findings highlight underappreciated roles for small RNAs externalized in NETs in the induction of proinflammatory responses in vascular cells, with implications for lupus vasculopathy.

Keyphrases

endothelial cells
induced apoptosis
systemic lupus erythematosus
cell cycle arrest
oxidative stress
disease activity
endoplasmic reticulum stress
signaling pathway
rheumatoid arthritis