O- Acetyl 1,3-Propanediol as an Acrolein Proelectrophile in Enantioselective Iridium-Catalyzed Carbonyl Allylation.
Katherine L VerboomCole C MeyerMadeline M EvartsWoo-Ok JungMichael J KrischePublished in: Organic letters (2023)
O -Acetyl 1,3-propanediol serves as an acrolein proelectrophile in π-allyliridium- C , O -benzoate-catalyzed carbonyl allylations mediated by racemic α-substituted allylic acetates. Using the iridium catalyst modified by ( R )-SEGPHOS, a variety of 3-hydroxy-1,5-hexadienes are formed with uniformly high levels of regio-, anti -diastereo-, and enantioselectivity.