Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood.

María Correa RodríguezSebastien ViatteJonathan MasseyJacqueline Schmidt-RioValleBlanca Rueda-MedinaGisela Orozco

Published in: BMC medical genetics (2017)

Our analysis of SNP-SNP interaction in candidate genes of QUS in Caucasian young adults reveal several interactions, especially between ESR1 and LRP5 genes, that did not reach statistical significance. Although our results do not support a relevant genetic contribution of SNP-SNP epistatic interactions to QUS in young adults, further studies in larger independent populations would be necessary to support these preliminary findings.

Keyphrases

genome wide
young adults
dna methylation
high density
copy number
genetic diversity
magnetic resonance imaging
high resolution
depressive symptoms
bone mineral density
gene expression
mass spectrometry
african american
single cell
estrogen receptor