Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability.

Anna SenrungTanya TripathiNikita AggarwalDivya JanjuaArun ChhokarJoni YadavApoorva ChaudharyKulbhushan ThakurTejveer SinghAlok Chandra Bharti

Published in: Cardiovascular & hematological agents in medicinal chemistry (2023)

The present study showed TC to possess anti-angiogenic potential via the inhibition of VEGFR-2. In addition, the study predicted TC to cross BBB as well as a safe alternative for GBM therapy, which needs further investigation.

Keyphrases

blood brain barrier
mesenchymal stem cells
risk assessment
bone marrow
climate change
smoking cessation