URINARY TRACT INFECTIONS: RENAL INTERCALATED CELLS PROTECT AGAINST PATHOGENS.
Forough ChelangarimiyandoabPriyanka MungaraManav BattaEmmanuelle CordatPublished in: Journal of the American Society of Nephrology : JASN (2023)
Urinary tract infections (UTIs) affect more than 1 in 2 women during their lifetime. Among these, more than 10 % of patients carry antibiotic-resistant bacterial strains, highlighting the urgent need to identify alternative treatments. While innate defence mechanisms are well characterized in the lower urinary tract, it is becoming evident that the collecting duct, the first renal segment encountered by invading uropathogenic bacteria, also contributes to bacterial clearance. However, the role of this segment is beginning to be understood. This review summarizes the current knowledge on collecting duct intercalated cells in urinary tract bacterial clearance. Understanding the innate protective role of the uroepithelium and of the collecting duct offers new opportunities for alternative therapeutic strategies.
Keyphrases
- urinary tract infection
- urinary tract
- induced apoptosis
- immune response
- escherichia coli
- cell cycle arrest
- end stage renal disease
- ejection fraction
- healthcare
- newly diagnosed
- chronic kidney disease
- polycystic ovary syndrome
- oxidative stress
- type diabetes
- pregnant women
- signaling pathway
- cell death
- endoplasmic reticulum stress
- adipose tissue
- insulin resistance
- pseudomonas aeruginosa
- pregnancy outcomes
- candida albicans